86" 



GENETIC STOCKS AND BREEDING METHODS 



with only those editing changes necessary to fit the format of this publication. It is 

 realized there are probably many strains now in the process of being developed that 

 will eventually be listed in future revisions by this Committee, or that will be indicated 

 in future editions of the Mouse News Letter. 90 * The importance of this species in mam- 

 malian genetic research is well recognized, and for this reason communication on the 

 location and status of murine material is much better organized than for the other 

 rodent species. The far-sighted organization of a committee for the purpose of bring- 

 ing order out of approaching chaos has been a tremendous asset, and consequently 

 there is little to add to the splendid work already done. Other kinds of useful informa- 

 tion about murine strains, such as composite-gene stocks, linkage stocks, and isogenic 

 stocks are available through such organizations as the Roscoe B. Jackson Memorial 

 Laboratory in this country and the various research groups in England that have 

 done an outstanding job in collecting such material and maintaining it in usable form. 



Table 27 

 Established strains of micej 



Name or 

 Symbol 



Synonym(s) 



Remarks 



A/Crgl/2 

 A/Crgl/3 



A/He 



A/Jax 



A/LN A Lilly 



inbr (St): 131. genet: aabbcc. H-2 a . origin: Strong, from cross 

 made in 1921 of albino from Cold Spring Harbor and Bagg albino. 

 The majority of sublines trace to a stock which Bittner obtained from 

 Strong in 1927. charac: mammary tumor incidence high in breeders, 

 low in virgins. Produces 5-10% young with cleft palate. High 

 incidence of renal disease in old mice, maintained by: Bcr, Br, Cam, 

 Fa, Fn, Ge, Go, Gr, H, Ha, Icrc, Lab, Mr, Not, Rl, Sn, Sp, Ss, St. 



inbr (Crgl): 26. genet: aabbcc. origin: from a nontumorous $ of 

 A/He-Jax. charac: 30-50% mammary tumors in breeders at 12-13 

 months. Originally very low incidence, maintained by: Crgl. 



inbr (Crgl): 18 since mutation, origin: mutation of MTI in 1951 at 

 F84 + 4. charac: over 90% mammary tumort in breeders at 8 

 months. Approx. 11% in virgins at 16 months, maintained by: 

 Crgl. 



inbr (Jax) : 111. genet: aabbcc. origin: see strain A. Strong to 

 Bittner 1927, to Heston 1938, to Jax 1948 at F 77 . charac: mammary 

 tumors 74% in breeders. Primary pulmonary tumors 30% in $?, 

 51% in o*6*- Mast-cell content of spleen very high in old mice, 

 especially 6\J- maintained by: Anl, Crgl, Cam, Cbi, Chr, De, Gif, 

 Ha, He, Jax, Mas, Mr, Ms, N, Per, Pi, Rd, We. 



inbr (Jax): 107. genet: aabbcc. origin: see strain A. Strong to 

 Cloudman 1928, survivors of Bar Harbor fire to Jax 1947 at F 73 . 

 charac: 28% mammary tumors in breeding $$. Primary pulmonary 

 tumors 41% in $$, 49% in o*6*- Lower percentage granulocytes than 

 other A sublines, maintained by: Anl, Bu, Chr, Fr, Jax, Jb, Ks, Mas. 



inbr (N): 110. genet: aabbcc. origin: see strain A. Strong 1921, 

 to Bittner 1927, to W. Murray, to Eli Lilly & Co. 1941, to Jax 1948, 

 to NIH 1951 at F 84 . charac: resistant to some tumors from other 

 A sublines, maintained by: N. 



t A list of abbreviations used is given at the end of this table. 



