94 GENETIC STOCKS AND BREEDING METHODS 



Table 27 — Continued 



Name or 

 Symbol 



Synonym(s) 



Remarks 



DBA 



DBA/1 



DBA/2 



dba, dilute 

 brown, dbr 



dilute brown, 

 dba, dbr, D/l 



D/2, D2, D, 

 dba subline 2, 

 subline 212, 

 dba-2 



DBA/2eB 

 DBAf dba„ 



DBAf-Z) 



DBA/1,- 



DBA/lo 



DBA-D DBAbr intense 



mutant subline 

 DBA/1-H-2 C D1.C 

 DBA-p 



DE 



CDE, cdE 



Simpson in 1948. (In view of the origin of this strain it should be 

 classed as a subline of DRA.) charac: low mammary tumor. 



MAINTAINED BY: Sp. 



inbr (Icrc): ? + 46. genet: aabbdd. origin: Little, 1909, from 

 mice used in color experiments, charac: high mammary tumors in 

 breeders, variable incidence in virgins, maintained by: Ch, Ha, Icrc, 

 Ms, Rl, S, Sp. 



inbr (Jax) : 36. genet: aabbdd. H-2". origin: Little, 1909. In 

 1929-30 some crosses were made between sublines and several new 

 sublines were established. Two of these were 12 (now called 1) and 

 212 (now called 2). DBA/1 to Fekete, 1936; to Jax market, to Hum- 

 mel, 1947, to Jax, 1948. charac: resistant to DBA/2 transplantable 

 tumors. Mammary tumors 80% in breeding females, maintained 

 by: Chr, Gif, Hu, Jax, Jb, Lab, Ma. 



inbr (Di): 68. genet: aabbdd. H-2 d . origin: see DBA/ 1 Jax. 

 Some sent to Mider and to Woolley, 1938; Mider to Heston, Heston to 

 Jax, 1948; Woolley to Dickie, 1949. charac: resistance to DBA/1 

 transplantable tumors. Mammary tumors 43% in breeding $$. 

 High incidence of nodular hyperplasia of adrenal after neonatal 

 gonadectomy; response accompanied by feminizing stimulation of 

 accessory reproductive organs. Audiogenic seizures 100% at 35d., 

 5% incidence after 55d. Onset of seizures at 14d. Does not develop 

 spontaneous leukemia, but susceptible to leukemia induction; poor 

 reproduction, maintained by: Cbi, Crgl, De, Di, Gif, Hn, Jax, Lab, 

 Ly, Mas, N, Oci, Pi, Sp., We. 



inbr (De) : 7 since transfer, genet: aabbdd. origin: from fertilized 

 ova of DBA/2 transferred to C57BL. maintained by: De. 

 inbr (Icrc): 31. genet: aabbdd. origin: sublines of DBA fostered 

 on C57BL or BD to remove milk factor, charac: low mammary 

 tumor, maintained by: Icrc, Sp. 



inbr (Sp) : ? + 13. genet: prob. aabbDd. origin: spontaneous 

 mutation from d to D in DBAf/Sp in 1951. charac: low mammary 

 tumor, maintained by: Sp. 



inbr (Hu): 20 since fostering, genet: aabbdd. origin: Hummel, 

 before 1950; DBA/1 fostered on C57BL/6. charac: low mammary 

 tumor incidence, otherwise like DBA/1, maintained by: Hu. 

 inbr (Hu) : 10 since transfer, genet: aabbdd. origin: Hummel, 

 from DBA/1 ovary transplanted to hybrid DBAf $ x C3HeB 6\ 1954. 

 charac: low mammary tumor incidence, otherwise like DBA/1. 

 maintained by: Hu. 



inbr (Ha): 21. genet: aabbDd. origin: spontaneous reverse muta- 

 tion from d to D in 1952. charac: H-2 d . maintained by: Ha. 

 inbr (Sn): G14F7. 



inbr (Sp) : ? + 6. genet: prob. aabbddpp. origin: spontaneous 

 mutation in DBA/MySp in 1957. maintained by: Sp. 

 inbr (Di): 31. genet: c e c e . origin: Eaton, in 1940, from a cross of 

 CE/Wy x E/Gw and selected for c e phenotype. Eaton to Woolley 

 1948, Woolley to Dickie 1949, to Jax 1954. charac: high incidence 

 (about 100%) of amyloidosis in spleen, liver, and adrenals; poor 

 breeders; no adrenal cortical carcinomas after neonatal gonadectomy. 

 maintained by: Di, Jax. 



