GENETIC STRAINS AND STOCKS 

 Table 27 — Continued 



91 



Name or 

 Symbol 



Synonym (s) 



Remarks 



C3H/Ks 



C3H/St Z 



C3Hf C3H b , C3H f , 



C3HfB 



C3Hff 



C3HeB/De C3He 



C3HeB/Fe TC3H 



C3H-//-P C3H.K 



C3H-//-2 6 C3H.SW 

 C3H-//-2" C3H.NB 

 C3H/Ha-/> 



C3H/He-.S7 Stock 800, 

 Steel 



C3H/N-W" Stock 93, W 

 C3HA 



inbr (Ks): 28. genet: +. origin: Strong, 1920. This stock from 

 C3H mice of unknown pedigree which survived the Bar Harbor 

 fire, charac: resistant to some C3H transplantable tumors. This 

 strain appears to fall into Bittner-Strong group of sublines on basis of 

 vertebral counts, but serological tests place the strain in the Andervont- 

 Heston group, maintained by: Jax, Ks. 



inbr (St): 114. genet: +. origin: Strong, 1920, from a cross of? 

 Bagg albino x o* DBA. Strains C, CBA and CHI originated from 

 this cross, charac: mammary cancer 70% at 14 months, and almost 

 100% in those living to 16 months. St and Bi sublines have pre- 

 dominantly 5 lumbar vertebrae, maintained by: Cbi, Fn, Ha, Sp, St, 

 Wi. Others maintaining C3H, subline not given: Ber, Ge, Ka, Pe, S. 



inbr (He): 39 since fostering, genet: +. origin: Heston, from 

 litter of C3H born by cesarean section and fostered on strain C57BL, 

 1945. charac: high susceptibility to MTI. Mammary tumor 

 incidence 2% in virgins, 38% in breeders, 20% in males treated with 

 diethylstilbestrol, none in untreated <$$. Heptomas 23% in diethyl- 

 stilbestrol-treated o*<J. maintained by: Anl, Cbi, De, Ge, Ha, He, 

 Ka, N, Pu, Sp. Another line fostered on C57BL by Fekete, maintained 

 by: Hu. 



inbr (Oci) : 3 since second fostering, genet: +. origin: from a 

 litter of C3H/He r fostered on a C3H/StHa ? in March 1958 at Ontario 

 Cancer Inst., to provide a strain with identical genetic background 

 to CSH/He^ but bearing milk factor, maintained by: Oci. 



inbr (De): 13. genet: +. origin: C3H/He ova transferred to 

 C57BL/6 by De. charac: mammary tumor incidence 4% in virgins, 

 55% in breeders, 74% in forcebred, and 22% in males treated with 

 diethylstilbestrol. Hepatomas 58% in virgins, 30% in breeders, 

 38% in force-bred, 55% in males treated with diethylstilbestrol, and 

 90% in breeding males, maintained by: De. 



inbr (Hu) : 31. genet: +. origin: C3H/He ova transferred to 

 C57BL/6 by Fekete in 1949, given to Hummel, charac: mammary 

 tumors 10% in breeders. Low sensitivity to FSH. maintained by: 

 Gif, Hu, Jax. 



inbr (Sn) : G14F13. genet: same as C3H except H-\ b substituted 



for H-\ a . 



inbr (Sn): G14F9. 



inbr (Sn): G16F9. 



inbr (Ha): 12 since mutation, genet: +p x pp. origin: spon- 

 taneous mutation at P-locus recovered in F 19 of C3H/He ; Ha. main- 

 tained by: Ha. 



inbr (Re): 12 since mutation, genet: Slsl. origin: mutation in 

 C3H/He at Oak Ridge, sent to Re in 1954. maintained by: Re. 



inbr (Re): 11 since mutation, genet: W'w. origin: mutation in 

 C3H/N to Russell, May 1955. maintained by: Re. 



inbr: 40. origin: C3H $ x A <$, subsequent inbreeding of their 

 descendants, charac: 37% mammary tumors in breeders, 45% in 

 virgins; about 25% of these metastasize to lungs. Liver tumors less 

 than 1%. maintained by: Lab. Exp. Oncology, AMN, U.S.S.R., 

 Mv. 



