MAMMALIAN RADIATION GENETICS 



153 



demonstrate that this procedure can be used to look for sublethals. Carter 158 tried 

 the linked-lethal procedure and came to the conclusion that it has no improvement in 

 efficiency over the specific-locus, test procedure. However, the procedure possibly 

 has not been exploited as far as it could be. 



Fig. 20. Congenital deformities produced by acute X irradiation of pregnant mice of 

 INBRED STRAIN C57/BL/K.S AT successive stages of gestation. 



STAGE IRRADIATED ( DAY « HOUR POST COITUM ) 



pTa fz*;o|gi<a[g«x^n»e [a»ao|g*»|g-»a>|l*« |x*-2o| 



ACEPHALY 

 CRANIOSCHISIS 



CYCLOPIA 

 ENCEPHALOCOELE 



OTOCEPHALY 

 EYE DEFECTS 

 BASE of CRANIUM ABNORMAL 

 8ASISPHENOID HOLE 

 CLEFT 

 PRESPHENOID DEFECTIVE 

 SCOLIOSIS of CRANIAL BASE 

 FACIAL PORTION of CRANIUM ABNORMAL 

 CLEFT PALATE 

 CLEFT PALATE- JAW- LIP 

 NASAL BONES ABNORMAL 

 BOTH JAWS 



UPPER JAWS CLEFT 

 " FUSED 

 LOWER JAWS REDUCE 

 FUSED 

 UPPER INCISORS ABNORMAL 



" " FUSED 



LOWER " ABNORMAL 



FUSED 

 MALFORMED VERTEBRAL COLUMN 

 VERTEBRAL CENTRA ABNORMAL 

 NEURAL ARCHES " 



RIBS • 

 STERN EBRAE 

 LUMBARIZATION and SACRALIZATION 

 TAIL ABNORMAL 

 POLYDACTYLY, HIND FOOT 



SUSCEPTIBLE STA«E 



peak or tusccmwLiTY 



Dr. Burdette: Would you comment on Dr. Degenhardt's first point? Is there 

 an effort to correlate research efforts on irradiation globally by the World Health 

 Organization and others? A summary of these activities should be of general interest. 



