250 PHYSIOLOGIC GENETICS 



Subcutaneous sarcomas C3H 



CBA 



Occurred spontaneously in 57 of 1774 



C3H and C3Hf $? 

 Most susceptible of 8 strains tested with 



carcinogenic hydrocarbons 

 High occurrence after sub-cutaneous 



injection of methylcholanthrene 



Stomach lesion 



BRS 1 



BRSUNTJ 



Occurs in practically all mice of this 

 strain 



Occurs following injection with methyl- 

 cholanthrene and spontaneously 



Adrenal cortical tumors 



CE 

 NH 



High occurrence following castration 1405 



High occurrence of spontaneous adeno- 

 ma 711 

 High occurrence of carcinoma following 



castration 419 



Teratomas, testicular 129 



1 per cent, congenital 



Interstitial-cell tumors of A 

 testis 



BALB/c 



Readily induced with estrogens (see 



Gardner) 

 High incidence following treatment 



with stilbestrol (Males tolerate stil- 



bestrol better than do those of other 



strains.) 



Pituitary adenoma 



C57BL 



Occurred in almost all mice treated with 

 estrogens 



Hemangioendotheliomas HR 



BALB/c 



19 to 33 per cent in untreated mice 

 54 to 76 per cent in mice injected with 



4-o-tolylazo-o-toluidine 

 High occurrence particularly in inter- 

 scapular fat pad and lung in mice 

 treated with o-aminoazotoluene 



Ovarian tumors 



C3He 



47 per cent in virgin $$; 37 per cent in 

 breeding $$; 29 per cent in force- 

 bred $? 



Myoepitheliomas 



A & BALB/c Occur in region of salivary gland and 



clitoral gland 790 



Harderian gland tumors C3H 



Occur in C3H and hybrids resulting from 



outcrossing C3H 563 - 571 



suggestions of strains best suited genetically for the study of each. Availability of 

 these strains is given in the complete listing of the strains by Dr. George Jay, Jr., to be 

 found in another chapter in this volume. 



It should be noted, however, that there are still a number of neoplasms of man, 

 the etiology of which should be studied in the laboratory but for which suitable inbred 

 strains are not available. Carcinoma of the cervix and uterus are among the more 

 important neoplasms of women but rarely occur in mice. Such neoplasms occurred 

 in the PM strain, but that strain was unfortunately lost because of sterility factors. 



