514 



APPENDIX 



wrote a paper some years ago, and it was in either the Journal of Genetics, Bibliographia 

 Genetica, or the Zeitschrift fur Induktive Abstammungs- und Vererbungslehre. I cannot 

 remember the title, but it was about the agouti series." The author file makes short 

 work of this, since the one making the request generally recognizes the reference when 

 confronted with it. It is found, of course, that the reference in question was from the 

 Annual Report of the Victoria and Albert Museum. 



Separating references according to periods of time also makes possible quantitative 

 surveys of the field and comparisons over the years (table 63). It comes as no surprise 



Table 63 



that cards with "neoplasm" punched have always accounted for about 50 per cent 

 of the total. When Dr. C. C. Little first began inbreeding mice during the first decade 

 of this century, his primary purpose was to have available dependable homogeneous 

 material with which to study the genetics of tumors. Also, it comes as no surprise that 

 studies using radiation as a tool or studies concerned somehow with viruses are increas- 

 ing steadily over the years, or that the interest in basic genetics, represented by the 

 "named genes" category, has held about the same level for the past 20 years. Mor- 

 phology, chemotherapy, tumor incidence, and irradiation effects are fairly popular 

 subjects, as are existence or characteristics of various pathologic states. A few of the 

 more unusual requests for information are the effects of exposure to white noise, 

 chemical composition of the mouse, development and morphology of teeth, and the 

 surface area of the peritoneum. 



Table 64, with its accompanying references, illustrates a different sort of approach 

 to the mass of information contained in the bibliography. This type of search is 

 done without regard to periods of time, by sorting for "origin" plus all the strains. 

 These references may not be in all cases the original ones. An attempt has been made 

 to list articles best describing the origin of the strain; in most cases multiple references are 

 supplementary, offering additional information or enabling the searcher to go from a 

 reference in which the strain is clearly named to one in which the real origin is given 

 but the mice are not so named. The many fostered strains have not been included, 



