236 Freeman, Pjncus, Elmadjian and Romanoff 



Summary 



A study was made of the adrenoeortieal responsivity of 34 

 elderly normal men and 33 aged schizophrenic patients 

 hospitalized for an average period of thirty years. Following 

 the injection of 25 mg. of ACTH and the ingestion of glucose 

 the blood and urinary functions under investigation showed 

 the same degree of dysfunction as had been noted in young 

 schizophrenic subjects. 



REFERENCES 



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DISCUSSION 



Nicolaysen: If you observe the urinary composition from tiie moment 

 you wake up and throughout the day, you observe cychc changes in 

 many constituents. The concentration may be nearly doubled from say 

 seven o'clock up to eleven, and then it falls back again — ^that's in 

 experiments with no food or water intake. 



Freeman: Well, diurnal variation is something we have to take into 

 considerati(jn always. As a matter of fact there isn't too much good 

 literature on this particular point, because individuals have been 

 studied at various times, but most of the experimenters have not got the 

 data for the exact hours in which our tests were performed. One can say 

 that although diurnal variation played a r61e in modifying the response 



