230 Freeman, Pincus, Elmadjian and Romanoff 



each function operates independently of the others. How 

 much of this is dependent on technical variation and how 

 much is due to inherent differential effects of adrenocortical 

 reactivity upon the various target organs or physiological 

 systems is impossible to assess. It does, however, make it 

 difficult to determine causal relationships. 



Table V 



Mean Values for Per Cent Changes from Basal Levels in Urinary 



Metabolites/Creatinine Ratios Four Hours After the Injection of 



25 MG. ACTH IN Elderly Normal (N) and Schizophrenic (S) Men 



The data on the response to glucose is shown in Table VI. 

 So far as the blood sugar is concerned, the trends in the two 

 groups are quite similar except that the patients show a 

 significantly greater elevation at the one-hour reading than 

 do the normal subjects. This decrease in tolerance is charac- 

 teristic of schizophrenic patients also (Pincus et al., 1949; 

 Freeman and Elmadjian, 1950). 



One of the usual concomitants of ageing is a tendency to 

 show a diabetic-like blood glucose trend, whether sugar is 

 given by mouth (Smith, 1948) or intravenously (Smith and 

 Shock, 1949). In young normal subjects the thirty-minute 

 value is usually higher than the sixty-minute reading. In old 

 normal subjects the thirty-minute reading is higher than that 

 of the younger individuals and the sixty-minute value is further 

 elevated over the thirty-minute one. In young schizophrenic 

 patients, the sixty-minute reading is usually higher than the 

 thirty-minute level, and in old schizophrenic subjects the 

 trend is exaggerated. The factors causing the reduction in 

 glucose tolerance of the schizophrenic patients are unknown. 



