Xll PREFACE 



in man and in certain animals as composed in early life of three 

 distinct physiological entities — the medulla, the cortex, and 

 the androgenic tissue. The last named term has been coined 

 to describe that portion of the adrenal which, in certain path- 

 ological conditions, gives rise to disorders of the reproductive 

 system. This view of the tripartite nature of the adrenal is 

 supported by many well-established facts. It affords a ra- 

 tional explanation of the relation of the adrenals to certain 

 pathological conditions of the reproductive system and avoids 

 assuming a relation between the cortex proper and the sex 

 glands as previous writers have unjustifiably done. 



Many of the views expressed in the present volume are based 

 on the results of experimental studies in which my colleagues, 

 to whom I am deeply indebted, have collaborated. Dr. War- 

 field M. Firor has performed surgical operations and enthusi- 

 astically cooperated in these researches; Dr. Evelyn Howard 

 is jointly responsible for the studies dealing with the relation 

 of the adrenals to the reproductive system; and Mr. Ellis 

 Grollman has aided in the preparation of the adrenal extracts. 



I wish also to express my sincere appreciation to the pub- 

 lishers for their cooperation and unfailing courtesies. 



A. G. 

 Baltimore, Maryland. 



