128 MEDULLA 



tic control, epinephrine injections fail to produce sweating. 378 

 Likewise in man, Elliott 177 obtained a decrease in secretion 

 from the skin of the hand, due probably to the accompanying 

 vasoconstriction. However, injecting epinephrine directly into 

 the pad of the cat's foot, after section of the sciatic nerve or 

 under deep anesthesia, produces sweating. 639 Also in the 

 horse, a localized area of sweating is induced by the subcutane- 

 ous injection of epinephrine which lasts for several hours. 262 ' 462 

 Intravenous injections cause generalized sweating. 



Cow's 131 demonstration of a vascular connection between 

 the adrenals and kidneys led him to suggest a functional rela- 

 tion between these two organs. In the dog, Marshall and 

 Kolls 438 found no such connection; nor does any apparently 

 occur in man. Addis, Barnett, and Shevky 270 found that sub- 

 cutaneous injections of epinephrine produced an increase in 

 urea secretion by the rabbit. Relatively large doses gave a 

 decrease. Intravenously injected epinephrine inhibits the 

 urine flow temporarily. The injection of 1 mgm. of epi- 

 nephrine diminishes diuresis and salt excretion in man. 639 



In animals with vesical fistulae, Zunz and his collaborators 699 

 also observed a diminution in the diuresis which follows the 

 ingestion of urea and in the proportion of chlorides in the urine 

 of fasting dogs after an injection of epinephrine. These effects 

 are probably to be attributed to the vascular effects induced 

 by epinephrine. Contraction of the blood vessels of the glo- 

 merular tuft would diminish the rate of urine flow while the 

 subsequent contraction of the efferent vessels from the glomeru- 

 lus would tend to increase the rate of filtration. 



Variable results have been obtained in studies of the effect 

 of epinephrine on gastric secretion. The secretion of milk is 

 not affected. Due to the ischaemia produced by epinephrine 

 the secretion of bile and pancreatic juice are inhibited. 170 



STRIATED MUSCLE 



Epinephrine (as does also stimulation of the sympathetic) 

 decreases fatiguability and increases the work capacity of an 



