152 CORTEX 



consists either in allowing cortical remnants of the main glands 

 to be left or in failing to remove the scattered accessory nests 

 of cells present in the peritoneal tissue in the neighborhood of 

 the glands. In every case of indefinite or prolonged survival, 

 microscopic examination has revealed the presence of hyper- 

 trophied cortical tissue in this region. The assumption of the 

 existence of widespread accessory tissue in other parts of the 

 body is entirely unnecessary (cf. Chapter II). 



The description of the operative procedure for adrenalectomy 

 in the rat shall be deferred to Chapter XVII where it shall be 

 described in connection with the assay of the cortical hormone. 



Adrenalectomy in the mouse and its consequences do not 

 differ from those observed in the rat and require no special 

 description. 198 The mouse is a useful experimental animal 

 involving studies on the androgenic zone which it possesses 

 (Chapter IV). 



Rabbit. The rabbit, like the rat, has been the subject of 

 much experimentation and controversy regarding the outcome 

 of adrenalectomy. Until recently it has been the general 

 opinion that a large percentage of rabbits survive the operation 

 due to the widespread occurrence of accessory bodies. This 

 view, however, as in the case of the rat, is erroneous and ex- 

 plicable by the great difficulty of performing a complete ex- 

 tirpation without so much manipulation and hemorrhage as to 

 kill the animal by operative shock. 



The rabbit's adrenals are very delicate and may be easily 

 torn. Such detached fragments may hypertrophy and explain 

 some of the survivals by "accessory bodies" reported in the 

 literature. 198 



The left gland lies about a half of a centimeter above the 

 upper pole and about one centimeter medial to the inner border 

 of the kidney. It lies in a hollow between the psoas and 

 quadratus lumborum muscles, in the angle formed by the vena 

 cava and the large vein which drains the lumbar muscles. 

 The right gland lies two to three centimeters cephalward of the 



