PHYSIOLOGY OF EPINEPHRINE 99 



apparently inhibits the reflex output of epinephrine and it is 

 necessary to view with scepticism all experiments on deter- 

 mining epinephrine secretion which were performed under 

 anesthesia. 548, 617 



In any case, the mobilization of carbohydrate observed after 

 stimulation of sensory nerves is not completely due to the 

 action of liberated epinephrine for some hyperglycemia is 

 obtained even in adrenalectomized animals. 345 - 346 



Bazett and Quinby 48 found that the pressor response of cats 

 under urethane anesthesia to sciatic stimulation was almost 

 entirely nervous in origin and not affected by adrenalectomy. 



Fastening an unanesthetized dog to the table, struggling, and 

 barking were all found by Satake, Sugawara, and Watanabe 546 

 to be accompanied by a marked increase in the epinephrine 

 secretion from the adrenals. 



Anesthesia. Anesthesia markedly affects the rate of secre- 

 tion of epinephrine from the adrenals. The epinephrine 

 content of the adrenals may be reduced to a half or a third of 

 its normal value. Section of the splanchnic nerves prevents 

 this depletion of the epinephrine stores. 178, 548, 617 



Asphyxia. That asphyxia affects the secretion of epineph- 

 rine as claimed by Anrep was not confirmed by the experi- 

 ments of Pearlman and Vincent, 488 nor by Stewart and 

 Rogoff. 587 



Hartman et alii, 210 on the other hand, found that asphyxia 

 causes mydriasis in the cat after excision of the superior 

 cervical ganglion. Adrenalectomy prevented the reaction. 

 Houssay and Molinelli 315 also noted a decrease in the volume 

 of a denervated limb during asphyxia, an effect not elicited 

 after cutting the splanchnic nerves or excising the adrenals. 

 The conflicting results of these various authors are to be 

 attributed to the different experimental methods utilized. 

 The type of asphyxia is also a matter of importance for al- 

 though asphyxia caused by inhalation of carbon monoxide 

 stimulates the secretion of epinephrine, low oxygen tension of 



