RELATION TO OTHER ENDOCRINES 



217 



rior lobe of the hypophysis. Besides the pathological findings 

 in acromegaly, Addison's disease, etc., other clinical conditions 

 present even more striking indications of a close pituitary- 

 adrenal relation. Thus Cushing's syndrome, in which one 

 finds basophilic adenomata of the hypophysis, and the adreno- 

 genital syndrome (to be described in Chapter XXIII) which 

 accompanies certain adrenal tumors, are often clinically in- 

 distinguishable due to their almost identical symptomatology. 



TABLE 1 



The body temperature of animals in a state of chronic adrenal insufficiency 

 The data in the table represent averages of daily temperatures obtained 

 during the course of one week. The average deviation of the individual 

 readings from the mean values recorded in the table was less than 0.3° (Groll- 

 man and Firor 248 ). 



Similarly the differential diagnosis of Simmond's disease (pitui- 

 tary cachexia) from Addison's disease is sometimes extremely 

 difficult. Both diseases share the common symptoms of 

 asthenia, anorexia, loss of weight, dizziness, and hypotension. 

 The question arises as to the extent to which adrenal insuffi- 

 ciency is responsible for these manifestations of a primary 

 pituitary disease and whether some of these symptoms as 

 observed in Addison's disease are not due to secondary effects 

 on the pituitary. The answer to these questions must be 

 sought in the effects of therapy with the adrenal cortical and 



