130 MEDULLA 



tion in rabbits after thyroidectomy. The rise, however, is 

 delayed somewhat in thyroidectomized animals and does not 

 last as long as it does in normal animals. 436 



The injection of epinephrine does not affect the protein 

 metabolism during exercise by a fasting man. The carbohy- 

 drate utilization, however, according to Dill and his collabora- 

 tors, 158 is increased considerably. There is also a decreased 

 excretion of acetone bodies indicative of the facilitating effect 

 of epinephrine on the oxidation of carbohydrate. Epinephrine 

 exerts the same effects on the blood sugar and lactic acid in 

 work as it does during rest. 



The above described results of Dill and his collaborators on 

 man are opposed to the earlier experiments on anesthetized 

 animals which purported to show that epinephrine inhibited 

 the utilization of carbohydrate in the body. This conclusion 

 which is based on an observed decline in the respiratory quo- 

 tient is open to serious objections. 419 



BODY TEMPERATURE 



In man, therapeutic doses of epinephrine cause a rise of 

 temperature of only a fraction of a degree. 544 In experimental 

 animals, however, marked fever can be induced. This hyper- 

 pyrexia is brought about by several factors. There is an in- 

 creased heat production accompanying the increased metabo- 

 lism, which is particularly striking in the liver. After removal 

 of the liver, fever can not be induced. The increased work of 

 the heart, under the influence of epinephrine, as well as the 

 increased activity of other organs and tissues stimulated by 

 epinephrine, all combine to give an increased heat production. 

 This heat is not dissipated because of the marked cutaneous 

 constriction which accompanies the reaction to epinephrine. 



Whether epinephrine causes hyperpyrexia by interference 

 with the heat regulating center is still debatable. Against the 

 assumption of such an interference is the fact that it raises 

 the temperature of the dog rendered poikilothermal by section 



