230 CORTEX 



islet tissue of the pancreas, is a hormone of such great impor- 

 tance for normal carbohydrate metabolism, one would logically 

 be inclined to seek an explanation of the abnormalities observed 

 in adrenal insufficiency in a disturbed pancreatic function. 

 Most of the work has been confined to the relation of the action 

 of insulin to epinephrine, which we have already considered in 

 previous chapters. The possible existence of a relation be- 

 tween the cortex and the activity of the islet tissue has not 

 been adequately studied. Since the hypophysis is also inti- 

 mately related to carbohydrate metabolism, some of the 

 changes observed in adrenal cortical insufficiency may be 

 secondary to hypophyseal dysfunction. Further work in this 

 field is necessary, however, before one can elucidate the rela- 

 tion, if any, which exists between the internal secretion of the 

 pancreas and that of the adrenals. 20 - 386 ' 402 - 424 



