178 CORTEX 



symptoms result from functional changes induced by the de- 

 ranged blood chemistry which accompanies cortical insuf- 

 ficiency. 



The changes found in the endocrine organs of animals dead 

 of adrenal insufficiency shall be considered in Chapter XIV. 



Despite the relative paucity of detailed studies of the ana- 

 tomical changes occurring in adrenal insufficiency, it is evident 

 that a number of tissues and organs manifest definite injury. 

 The manifold nature of the symptomatology of adrenal insuf- 

 ficiency is indicative of a widespread involvement of many 

 organs. The available experimental data is still too meager, 

 however, to permit one to define accurately the relation of the 

 various clinical symptoms to the different organs responsible 

 for them and further work along these lines is indicated. It is 

 desirable, however, in making such studies to maintain the 

 experimental animals on an adequate dose of the cortical hor- 

 mone after adrenalectomy until all effects of the operation have 

 disappeared. In this way one avoids the effects of trauma and 

 anesthesia and allows the animal to survive for a longer period 

 during which the changes due to insufficiency can develop. 



