RELATION TO OTHER ENDOCRINES 211 



changes in the eosinophilic and chromophobic cells were not as 

 striking as the changes observed in the basophilic cells. 



In determining the relative roles played by the adrenal cor- 

 tex and the pituitary in the symptomatology of a primary 

 adrenal or pituitary dysfunction, it is necessary to differentiate 

 between the effects of acute and chronic insufficiency. The 

 stunted growth, subnormal body temperature, and reduced 

 reproductive and body activity of hypophysectomized animals 

 cannot be remedied by treatment with large amounts of the 

 adrenal cortical hormone. This would indicate that the 

 symptoms of hypophyseal insufficiency are not due to a sec- 

 ondarily induced adrenal cortical insufficiency. Nor can the 

 stunted growth, sub-normal body temperature, and reduced 

 body activity of adrenalectomized animals be remedied by the 

 injection of the anterior pituitary hormone. Hence we must 

 conclude that these symptoms of acute adrenal insufficiency 

 are not attributable to a secondarily induced hypophyseal 

 insufficiency. It is true that in animals in diestrus as a result 

 of adrenal insufficiency, estrus can be induced by the injection 

 of large doses of estrogenic or gonadotropic hormones. 567 This 

 is not, however, an indisputable proof that the initial reproduc- 

 tive dysfunction resulting from adrenal insufficiency is hypo- 

 physeal in origin. The pituitary gland of hypophysectomized 

 rats has, however, been shown to be deficient in gonad-stimu- 

 lating power, which is presumptive evidence for the view that 

 pituitary dysfunction may be responsible for the abeyance of 

 the estrus cycle in adrenalectomized rats. The general de- 

 bility and cachexia of animals in adrenal insufficiency, how- 

 ever, can also be held responsible for the abeyance of reproduc- 

 tive activity. 



Although no good evidence exists for attributing the symp- 

 toms observed in acute adrenal insufficiency to pituitary dys- 

 function and vice versa, the anatomical findings already cited 

 would indicate that chronic adrenal insufficiency does result 

 in pituitary injury. Such injury, as one would anticipate, will 



