156 



COKTEX 



The survival of dogs after a single-stage adrenalectomy 

 under spinal anesthesia is indicated in the following table of 

 Firor and his collaborators: 251 



Cat. The ready availability of the cat and the relative 

 ease with which its adrenals can be extirpated have made it a 

 favorite animal for this type of experiment. The classic study 

 of adrenalectomy and its effects in the cat is that of Elliott. 180 

 He removed the glands of 25 animals in stages with an interval 

 of 3 to 9 months between the two operations and observed a 

 survival which ranged from 6 to 23 days. Elliott avoided the 

 splanchnic nerves in his operation. 



Cats withstand the effects of adrenalectomy well and their 

 survival period is usually much longer than it is in dogs. The 

 glands are situated in less intimate contact with the large 

 vessels than they are in the dog and hence are more easily 

 removed. Extraperitoneal excision through a lumbar incision 

 as in the dog is to be preferred, for much less trauma is in- 

 flicted by this approach than when the glands are removed 

 through an abdominal incision. 



Even after extirpation under ether anesthesia and by a one- 

 stage operation, most cats survive 3 to 7 days when the opera- 

 tion is properly performed. The use of a more satisfactory 

 anesthetic and extirpation in two stages should give much 

 longer survivals. The average survival of cats after a two- 

 stage operation was found to be 11 days by Rogoff and 

 Stewart. 634 Swingle and Pfiffner 613 found an average survival 

 of 7.7 days while Britton in the single stage operation reports 

 an average survival of 7.5 days. 86 



Other mammals. Adrenalectomy has been performed in a 

 few cases in monkeys. In these animals, the adrenals are 



