160 CORTEX 



responsible for the fatal outcome which follows adrenalectomy 

 is now generally accepted as an incontrovertible fact. Many 

 lines of evidence might be cited to support this conclusion. 

 The fact that cortical extracts free of epinephrine even when ad- 

 ministered orally maintain adrenalectomized animals in normal 

 physiological condition is the most direct proof that absence 

 of the cortical secretion alone is responsible for all of the 

 manifestations which follow adrenalectomy. The possible im- 

 portance of the medullary secretion has already been discussed 

 in Chapter VI. 



