PHYSIOLOGY OF CORTICAL INSUFFICIENCY 



165 



hyperpnoea a particular importance in producing the manifes- 

 tations of insufficiency. However, this view is not tenable for 

 it is only in animals dying soon after adrenalectomy that one 

 observes any unusual hyperpnoea. Thus in one of Bornstein 

 and Holm's 71 experiments the basal respiratory minute volume 

 of a dog rose from 2.53 liters per minute to 7.19 liters, with a 

 drop in the C0 2 tension of the alveolar air from 4.27 per cent 



y 5 



"Hi 

 •*« 



■X40 USO 



I 



§3? // 40 



30/030 



Days sifter /jafrenateciomj/ 



80 SO 60 

 -I ^ 



7 \k 



Fig. 10. Changes in Various Physiological Functions in Adrenal 

 Insufficiency 



Composite records of results obtained on dogs adrenalectomized in stages. 

 The animals received no therapy during the period of observation and died 

 seven days following the removal of the second gland. 



to 1.18 per cent; the body temperature fell from 38.2° to 

 35.7°; the oxygen consumption fell from 109.6 cc. to 82.5 cc; 

 and death occurred 7f hours after the operation. The changes 

 observed in this case must be attributed in great part to opera- 

 tive shock. 



In animals which have survived for some time and then gone 

 into insufficiency, the respiration is usually slow and not easily 



