282 COKTEX 



an optimism that we now would deride. Thus Bra 119 trans- 

 planted the adrenals of a dog into the cellular tissue of the 

 abdomen in a child with Addison's disease. Death followed 

 in three days. Jaboulay's two cases died within 24 hours 

 following a similar transplantation as did also the patient of 

 Courmont. 1 * 9 In view of the fact that the transplantation of 

 human tissue is fraught with the greatest of difficulties, one is 

 forced to disregard the claims of all early investigators who 

 optimistically report favorable results from transplants of pig, 

 sheep, and dog adrenals into patients suffering from Addison's 

 disease. The introduction of foreign protein and the necessary 

 operative procedures could only have aggravated the adrenal 

 insufficiency of these patients. The small amounts of hor- 

 mone present in the transplanted tissues were too minute to 

 exert even any temporary amelioration which, when it oc- 

 curred, must have been due to the natural remissions so com- 

 mon in Addison's disease. 



Attempts have also been made to transplant the adrenals of 

 premature fetuses into patients suffering from Addison's 

 disease. In most cases the patients were in the late stages of 

 the disease and the shock of the operative procedure hastened 

 the onset of death. In only one case was success reported with 

 recovery of the patient but when the latter, some years later, 

 came to autopsy it was found that his adrenals were normal, 

 that he had never had Addison's disease, and that the as- 

 sumedly successful grafts into the testicle had undergone 

 atrophy. 122 Other cures have been reported but must be 

 viewed with scepticism. 145 



In animal experiments, on the other hand, successful grafts 

 and transplants of the adrenals have been made by several 

 investigators, despite the failures of many of the earlier workers 

 who failed to appreciate the difficulties attendant upon trans- 

 planting any tissue to a new host. Boinet's intraperitoneal 

 grafts in rats were unsuccessful as were also those of Strehl 

 and Weiss, 600 and Hultgren and Anderson's 323 intramuscular 



