SURGERY 283 



grafts in cats and rabbits. In Poll's subcutaneous grafts 

 some regeneration of the cortex occurred while the medullary 

 tissue disappeared. Similar results were obtained by grafts 

 in the omentum of the rat by H. and A. Cristiani. 137 



Stilling 597 found cortical tissue grafted into the testicle of 

 a rabbit to be active after three years. Busch, Leonard, and 

 Wright 145 made successful grafts into the kidneys of rab- 

 bits which maintained life after bilateral adrenalectomy. 

 Death followed the removal of the grafts. In none of the 

 above cases was medullary activity demonstrable, the medulla 

 always disappearing in the transplanted tissue. 



Abelous and Langlois 4 successfully transplanted adrenal 

 tissue into the lymph sacs of frogs. Abelous was also suc- 

 cessful in producing homotransplants into the ileo-coccygeal 

 muscles, the subsequent removal of which in previously 

 adrenalectomized animals caused the frogs to manifest the 

 typical symptoms of adrenal insufficiency. 



In recent years, grafting of adrenal tissue has been per- 

 formed successfully in guinea pigs and rats. Elliott and 

 Tuckett 183 found the subcutaneous tissues of the guinea pig to 

 be peculiarly sensitive to adrenal grafts. The irritant sub- 

 stance inducing this tissue reaction to grafts of guinea pig 

 adrenals, occurred chiefly in the medulla but was almost 

 absent from the adrenals of carnivores and was not, therefore, 

 epinephrine. Jaffe, 334 however, found that autoplastic trans- 

 plants into the abdominal wall of guinea pigs remained for 

 months, growing to fairly large size. Homoplastic transplants, 

 on the other hand, usually degenerated after a few months. 

 Small autoplastic transplants maintained the life of completely 

 adrenalectomized animals for weeks while large transplants 

 maintained them indefinitely in good condition. In these 

 experiments Jaffe avoided the transplantation of medullary 

 tissue, transferring small bits of the cortical tissue, after wash- 

 ing in saline, into pockets in the muscle of the abdominal wall. 



In the rat, Jaffe 333 and Wyman and Suden 692 have obtained 



