284 CORTEX 



successful autoplastic transplants in a large fraction of their 

 animals. Homoplastic transplants are also successful in the 

 rat but heteroplastic transplants have not been achieved. The 

 growth of transplants is contingent upon a physiological need 

 for their secretion and hence such transplants can not be used 

 to induce hyperfunction of the cortical tissue. The total 

 amount of tissue regenerating is fairly constant and limited by 

 the needs of the organism and the amount of functional tissue 

 already present in the animal. 692 



The oft-quoted successful transplants of Haberer 261 are 

 not really grafts but consist merely in transferring the whole 

 adrenal after dislocating it from its peritoneal attachments to 

 an incision into the kidney. The blood vessels to the gland are 

 left intact. Such dislocated glands continue to grow in the 

 kidney without suffering degeneration even of the medullary 

 tissue. 



The medullary tissue shares the property of nervous tissue 

 generally, to which it is embryologically related, in showing 

 little or no regenerative capacity. Hence in transplants of 

 whole glands the medulla soon degenerates. 141 Undoubtedly 

 the liberation of epinephrine from the degenerating medulla 

 will inhibit growth of the cortical cells and hence one should 

 only use the outer zone of the cortex (which constitutes the 

 active regenerative tissue) in transplants. The abdominal 

 muscles, ovaries, testicles, kidneys, and subcutaneous tissue 

 of the axilla have been favored as the most practical sites for 

 successful transplants. 



In recent years, the effort to transplant cortical tissue into 

 patients with Addison's disease has been revived, but thus far 

 no convincing report of any success has beeen published. 

 One of Beer and Oppenheim's 49 two patients showed micro- 

 scopic areas of functional tissue at autopsy two weeks after the 

 transplant. The other patient improved after the transplant, 

 but such improvement must be attributed to a natural re- 

 mission for it is inconceivable that the minute amount of 



