PREPARATION OF CORTICAL HORMONE 



243 



Results similar to those of Figure 13 are obtained when the 

 eluted hormone or the extract prepared for parenteral adminis- 

 tration are utilized as is shown in Figure 16. 



DOSAGE 



There has been no investigation of the dose of the adrenal 

 cortical hormone required by man. This will obviously be a 

 variable dependent on the severity of the adrenal insufficiency 



TABLE 2 



The adrenal cortical hormone requirement of various animal species 

 (Grollman and Firor 249 ) 



ANIMAL SPECIES 



Mouse. 

 Rat... 

 Cat... 

 Dog... 



Alan*.. 



RAT UNITS OF 

 HORMONE 

 NECESSARY 



PER DAY 

 FOLLOWING 

 ADRENAL- 

 ECTOMY 



1.0 

 3.5 



20 



55 



220* 



RAT UNITS PER 

 SQUARE METER 

 OF BODY SUR- 

 FACE PER DAY 



120 

 97 

 125 

 120 



* The value for man is estimated from the data obtained on the experi- 

 mental animals, assuming the human requirement to be proportional to the 

 surface area. 



in a given patient. For practical purposes, however, it is 

 essential to know approximately the amount of hormone neces- 

 sary to supply the needs of an individual. This value may be 

 derived indirectly from the data of Table 2, and is based on 

 the hormone requirement of adrenalectomized mice, rats, cats, 

 and dogs. The fourth column of the table records the average 

 surface area of the animals studied as calculated from their 

 body weight, using Rubner's data for the value of the constant 

 in Meeh's formula. The fifth column records the average dose 

 of the hormone necessary to maintain life in the adrenalecto- 



