152 



INANITION AND MALNUTRITION 



bones, and in different individuals according to age and to the stage and inten- 

 sity of the disorder, the structural changes in general involve a fibroid and 



Fig. 56. — From a photograph of a portion of a section through the costochondral joint of a 

 young guinea pig on a diet of oats and milk-powder for 10 days; body weight reduced from 

 273 g. to 212 g. Incipient scurvy. C, costal cartilage; Z, zone of enchondral ossification, 

 largely replaced by fibroid marrow; M, more nearly normal costal marrow; D, bone of costal 

 diaphysis; P, adjacent periosteum and (atrophic) muscle. Zenker fixation, hematoxylin- 

 eosin stain. X40. (Preparation by Everett Rowles.) 





Fig. 57. — From a photograph of a portion of the enlarged costochondral junction of a 

 young guinea pig; body weight reduced from 254 g. to 169 g. in 21 days on a diet of oats and 

 milk-powder, with death from scurvy. C, costal cartilage; Z, irregular zone of echondral 

 ossification; H, zone of fibroid marrow with distended blood vessels and hemorrhages; F, zone 

 of non-hemorrhagic fibroid marrow; M, more nearly normal marrow; D, bone of costal dia- 

 physis; P, adjacent periosteum, hemorrhagic, with markedly atrophic muscle. X40. (Prepa- 

 ration by Everett Rowles.) 



hemorrhagic degeneration of the marrow, with associated inhibition of osteogenesis 

 and atrophy of the preexisting bone. 



