424 



INANITION AND MALNUTRITION 



Ponomarew ('14), on the contrary, obtained in white mice during complete 

 inanition (also on carbohydrate or protein diets) a decrease in the suprarenal 

 fats. These often disappear completely in the zona fasciculata and zona retic- 

 ularis, though a small quantity is constantly retained in the zona glomerulosa 

 (and spongiosa). This applies in general to the neutral fats and fatty acids. 



mm mms^&i 



Fig. 105. — Portion of a section of the suprarenal gland of a normal male albino rat (J. i.i) 

 3 weeks old. Most of the middle part of the cortical zone is omitted. F, fibrous capsule; 

 O, outer zone (glomerulosa); showing one cell in mitosis; T, transition band, nearly lipoid-free; 

 Mo, outer part, and Mi, inner part of middle zone (fasciculata) ; 7, inner zone (reticularis) ; 

 M, small portion of medulla. Zenker fixation; hematoxylin-eosin stain. X300. (Jackson 

 *I9-) 



liWr^fM'^'^W: 



ry- 



limpid M :S»i«S 



f T Mo I M 



Fig. 106. — Portion of a section of the suprarenal gland of a male albino rat (S. 7.31) held 

 at constant body weight by underfeeding from 3 to 10 weeks of age. X300. For explanations 

 see Fig. 105. There is a progressive differentiation of lipoidal vacuoles in the outer zone (O), 

 and of pigment (P) in the inner zone (7) ; also some cell atrophy, with hyperemia and increased 

 degeneration in the inner cortical zone. (Jackson '19.) 



The lipoids (cholesterin,phosphatids, etc.), which lie on the surface of the neutral 

 fat droplets, disappear in the same order, but in the last stages of starvation 

 appear relatively less abundant than the neutral fats. Ponomarew favors the 

 infiltration theory (versus the secretion theory) of the origin of the suprarenal 

 fats. 



Rondoni and Montagnani ('15) in guinea pigs on complete inanition (water 

 only) or incomplete inanition likewise noted a reduction in the cortical fats 

 (osmophile and sudanophile) ; also congestion, atrophic degeneration in some 



