EFFECTS ON THE SUPRARENAL GLANDS 



425 



cells, and a decreased amount of pigment in the zona reticularis. Rothschild 

 ('15), however, found an increased cholesterin content in the suprarenals, as 

 well as in the blood, liver and bile, of fasting rabbits. 



Jackson ('19) studied the effects of inanition upon the suprarenal in both 

 young and adult albino rats. The ratio of cortex to medulla is not materially 







?SL. otKrifm* •-*«( ^>Ssrs&* T*?>iiL 'A'iiA' - Vr«S j -iv ~^-ii -~ !pbi>.\ • -:? -^JflhtW i ^-^ 



ass 



* >W 



Mo i^ m~ 



Fig. 107. — Portion of a section of the suprarenal gland of a normal male albino rat (St. 

 47.5) 10 weeks old. X300. For explanations, see Fig. 105. This represents the normal 

 adult structure. Lipoidal vacuoles are well marked in the outer zone (O), and outer part of 

 the middle zone (Mo), but rare in the transition band (T). A mass of pigment (P) is visible 

 in the inner zone. (Jackson '19.) 



Ssk#M^PPs1& 



Pilliflltll ^K|&S^ 



*K2 







'.ft ■ W 



.va 



ldo^BIF 







Fig. 108. — Portion of a section of the suprarenal gland of an adult male albino rat (J. 1.5) 

 subjected to chronic inanition 5 weeks, with loss of 34 per cent in body weight. X300. For 

 explanations, see Fig. 105. The lipoidal vacuoles have disappeared, except in the outer 

 zone (0). There is marked atrophy with nuclear and cytoplasmic degeneration in the inner 

 cortical zone (7). Three pigment masses (P) are visible. (Jackson '19.) 



changed during inanition. Hyperemia is marked in the zona reticularis. In 

 young rats during underfeeding the change in size of cortical cells and nuclei is 

 variable, some increasing, some decreasing, some remaining unchanged. The 

 cortical cells develop liposomes (as normally) but in variable amount (Figs. 

 105 and 106). In some cases, many cells undergo atrophic degeneration, 

 especially toward the inner zone. Pigment appears in unusual abundance. 

 Mitosis is more or less completely suppressed, but upon refeeding it is resumed, 

 and normal conditions are nearly restored in two weeks. 



