456 INANITION AND MALNUTRITION 



hypophysis, as in the suprarenal glands, the sex differences in the normal weight 

 of the glands must be considered. 



According to van Driel, the hypophysis and suprarenal are exceptional in 

 that they do not atrophy like the other endocrine glands as a result of dietary 

 deficiency of vitamin B. Findlay ('21) found the hypophysis (pituitary) practi- 

 cally unchanged in weight in pigeons and fowls on polished rice diet, with a 

 slight apparent hypertrophy (2.5-6 per cent) during acute and chronic inani- 

 tion (Table 13). 



In guinea pigs on a scorbutic diet, Bessesen ('23) found a progressive hyper- 

 trophy of the hypophysis, increasing in the various groups from 8 per cent after 

 5 days to 50.5 per cent at death from scurvy (Table 12). 



In adult albino rats during aqueous inanition (on dry diet), Kudo ('21) 

 found the weight of the hypophysis practically unchanged in both acute and 

 chronic thirst series, in spite of a loss of 36-52 per cent in body weight (Table 

 9). In one rat on total inanition the hypophysis apparently increased 8.3 

 per cent in weight. In young albino rats held at constant body weight by a 

 relatively dry diet for various periods, beginning at about 4 weeks of age, 

 Kudo ('21a) found but slight change in the average weight of the hypophysis 

 in the shorter test periods, but a definite hypertrophy (37.5-43.8 per cent 

 in the longer experiments (Table 10). 



