/I/ Deficiency signs, when not Irreversible, may be alleviated and the animal restored to health by administration of 

 therapeutic doses of the vitamin. /5/ Spontaneous deficiency is extremely rare, although reported for the chick. Feed- 

 ing of raw egg white (active agent, avldln) is necessary to produce deficiency signs In animals. Avidin and blotin form 

 a complex in the intestine which renders the vitamin unavailable to the organisms. /6/ The following therapeutic uses of 

 choline have been noted: cure of fatty liver and certain forms of liver cirrhosis (dog, rat); prevention of perosia 

 ("slipped tendon" (chicken, turkey)). 



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