/l/ Deficiency signs, when not irreversible, may be alleviated and the ^pliya l restored to health by administration of 

 therapeutic doses of the vitamin. /?/ Some synthesis of CH3 occurs in the metabolism of glycine, alanine, serine, 

 histidine, tryptophan. /8/ Probably identical with the antl -pernicious anemia principle of liver. /9/ The following 

 therapeutic usee of cobalamln have been noted: Treatment of pernicious anemia — the vitamin is anti-anemic, relieves 

 the lingual manifestations and reverses the degenerative changes in the spinal cord unless damage Is irreversible (Man); 

 treatment of sprue (Man), /lo/ Some causes of deficiency st^s, other than dietary deficiency of the vitamin, are: any 

 factor impairing digestion or absorption of fat, as inflammation of intestinal mucosa, sprue, or chronic diarrhea; 

 excessive ingestion of minereJ. oil; relatively greater requirement during pregnancy and lactation. /n/ The amount of 

 dietary vitamin D which will produce sims of excess varies with individuals within the same species, and at different 

 times within the same IndlvidusLl. /l2/Skeletal abnormalities and deformities are the scars and residue of functional 

 and structural, change and may persist long after the deficiency has been relieved. Degree of restoration may be exten- 

 sive and continue over long periods. 



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