/l/ Deficiency signs, when not irreversible, may be alleviated and the ft n lnw T. restored to heaJ-th by adjalnlstration cf ther- 

 apeutic doses of the vitamin, /ik/ The folloving therapeutic uses of the vitamin have been noted: Treatment of sprue (man); 

 nutritional macrocytic anemia; certain megaloblastic, macrocytic anonias of infancy (man); macrocytic anemia of pregnancy 

 (nan); added to practical rations as a grovth stimulation factor (mink). Folic acid antagonists, e.g., aminopterin, used 

 in treatment of leukemia and certain other diseases (man). /15/ Intravenous LD5o=^*^ i^g/*^ body weight (mouse); 5OO mg/kg 

 (rat); 1*10 mg/kg (rabbit); 120 mg/kg (guinea pig). 



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