SESSILE AND HUMORAL ANTIBODIES 



219 



only, and others received a combination of cell and serum treat- 

 ment. Three mice from each group were killed on the 7th and 

 9th days respectively after injection of the tumour. The ascitic 

 fluid from each was measured and counts of both tumour and 

 host cells made. The mean cell number of each group was 

 determined, and the differences between groups calculated. 

 Standard errors of the differences between groups confirm the 

 statistical significance of the results. 



Unlike the conclusions reached from the experiments in which 

 BP 8 was transplanted subcutaneously, results were obtained 

 demonstrating an antagonistic relationship between sensitized 

 cells and isoantiserum. Some inhibition of tumour growth was 

 produced by one million sensitized cells, and higher doses led to 

 greater suppression. If the cell-treated animals were also given 

 isoantibody, interference with this inhibition resulted. Table I 



Table I 



Antagonistic effect of antiserum upon the inhibition of intraperitoneal 

 growth of bp 8 caused by sensitized cells 



Experiment 



6/3 < 



21/3 



* These differences are not included as they are irrelevant to the experimental 

 conclusions. 



