DISCUSSION 117 



did you consider trying it mechanically ? As soon as it has holes in it, 

 rejection should occur. 



Billingham: Peppering these established grafts with a fine syringe 

 needle didn't cause rejection. 



Eichwald: From the inside or the outside ? 



Billingham: From the outside. 



Eichwald: Of course you don't remove the plug, and it will seal up 

 like a valve ; but if you could break it from underneath by raising the 

 skin flap and then lacerating it, that might be effective. 



Billingham: That's worth trying. 



Woodruff: Is it possible you are producing a sort of local lymphatic 

 blockade ? — that some of the material absorbed from this slime fmds its 

 way into regional lymph nodes and clogs them up ? 



Billingham: I couldn't exclude that possibility on the basis of our 

 present knowledge. 



TRANS. — 5 



