DISCUSSION 153 



cortisone extends the period during which a given dose of 

 homologous cells will induce tolerance in nursling rats. A natural 

 extension of this idea into clinical practice is the possible use of 

 anti-lymphoid agents to mediate the induction of specific 

 tolerance to transplanted organs. 



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DISCUSSION 



Hildemann: I am most impressed with the excellence of the design of 

 these experiments, and I think there will be many future applications of 

 this technique. In our hands, splenic enlargement has turned out to be 

 highly variable in graft-versus-host reactions. The occurrence and 

 extent of splenic enlargement depend upon the stage of runt disease and 



