IMMUNOGENETICS OF TUMOURS GROWN IN 

 RADIATION CHIMERAS 



Michael Feldman and David Yaffe 



Section of Cell Biology, Weizmann Institute of Science, Rehovoth 



Tumour transplantation in radiation chimeras has been studied 

 from three distinct viewpoints: (i) to test the immunological 

 competence of radiation chimeras, and the cellular origin of the 

 immune response; (2) to study certain aspects of the tumour-host 

 relationship, particularly host factors determining the formation 

 of tumour metastasis; and (3) to study changes in the immuno- 

 genetic properties of tumour cell populations. The present 

 discussion v^ill deal with the problem of tumour metastasis, and 

 with the immunogenetic properties of tumour cells, as revealed 

 by transplantations in radiation chimeras. 



Table I 

 The formation of a homograft reaction against tumour transplants in 



ISOLOGOUS radiation CHIMERAS 



Tumours Tumour-bearing 



grafted Radiation chimeras animals 



\Ar.\A /C57BL spleen ceUs -^CsyBL o/ii 



ML.IM ^C57BL foetal Uver ceUs->C57BL 7/7 



^ /C57BL spleen cells ->C57BL o/io 



IC57BL foetal liver cells->C57BL 5/5 



Cio 



/C3H spleen cells -^CsH 10/10 



\C3H foetal liver cells ->C3H 10/10 



Table I illustrates the type of tumour chimera system used in 

 our experiments, and the capacity of the donor cells to form 

 transplantation immunity against the tumour homograft. We 



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