326 DISCUSSION 



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DISCUSSION 



Medawar: Dr. Voisin, have you tried the effect of these antisera on 

 the runting capabilities of ;?resensitized CBA cells? If you compared 

 presensitized with normal CBA cells it would help you to find out 

 whether the antiserum was acting on the tissues of the A-hne host and 

 protecting them against the attack of CBA cells, or whether it was 

 diminishing the immunological capabilities of the CBA cells themselves. 

 These correspond to efferent and central inhibition. 



Voisin: No, we have not tried that. As a matter of fact, this is a 

 problem which is extremely interesting per se, but it was not the point 

 we wanted to make in these experiments. It will be the subject of 

 further experiments. 



MicJiie: Does anybody know what runts die of— is it anaemia or 

 liver damage ? 



Voisin: I do not know. And I doubt whether anyone knows exactly 

 what is the ultimate cause of death in runting — or what is the ultimate 

 cause of death in many other diseases. But the general mechanism of 



