420 



SUBJECT INDEX 



Liver, foetal cells of, tolerance 

 mediated by, 253, 257, 267-268 



in runt disease, 354, 357 



transplantation antigens in, 3 8 

 Liver weight, in assay of runt disease, 



248-250, 257, 266-267 

 Loss mutations, as basis of clonal 



selection theory, 202-204, 207 

 Lymphatic drainage, role in survival 



of homografts, 98, 103, 113, 114 

 Lymph node, 109 



in runt disease, 358 



role in transplantation, 109, 113 



tumour resistance in, 1 81-182 

 Lymph node cells, injection of causing 



runt disease, 379-380 

 Lymph node metastases, 181 



from sarcomas in radiation chi- 

 meras, 165, 167 

 Lymphocytes, 3 



counts, 239 



development of, 259, 264-265 



differences in action, 382 



effect of thymectomy on, 394, 399 



immune response of, 259-260 



immunological competence of, 

 236-270 



in development of tolerance, 155, 

 156 



in spleen, in newborn and adult, 152 



mitotic potentiahties, 240 



preparation of, 238-239 



role in skin graft survival, 98, 103, 



113, 114 

 role in transplantation immunity, 



260 

 role of thymus in migration of, 399 

 runt disease due to, 240-241 



characterization of cells used, 

 241-242 



chimerism among survivors, 

 252-253, 265, 268, 269 



in hybrids, 253-254, 255, 257-258 



Lymphocytes, 



runt disease due to, 



organ-enlargement assays, 246- 



251, 257, 266-267 

 role of cell dosage, 242-246, 255 

 weight-gain assay, 246-251, 266 

 transformation of, 264-265, 269-270 

 Lymphoid cells, disruption of, 8 

 Lymphoid tissue, following thy- 

 mectomy, 388-389 

 replacement of, 1 41-142 

 role in tum^our transplantation, 

 180-181 

 Lymphoma, transplantation of, 182- 



183 

 Lysolecithin, 87 



Magnesium chloride, effect on trans- 

 plantation antigens, 9, 10 

 Mammary adenocarcinoma, meta- 

 stases from in radiation chimeras, 

 167-168 

 6-Mercaptopurine, 369 

 Metastasis, effect of cortisone, 183-184 

 in X-irradiated isologous systems, 

 165-169 

 Methotrexate, see Amethopterin 

 Methylcholanthrene, tumours pro- 

 duced by, 169 

 6 - ( I - Methyl - 4 - nitro -5- imidazolyl) 

 thiopurine, in treatment of runt 

 disease, 352, 369-370 

 Mother-foetus immunological rela- 

 tionship, 21, 1 1 8-1 3 7 

 absence of homotransplantation 

 reaction, reasons for, 11 8-1 19, 

 129 

 anatomical barrier to antibodies, 



119, 127, 131, 132, 133-135 

 induced tolerance in mother, 122 



Newborn, enhancement in, 294 

 immunization of, 144-149, 157, 

 160, 161-162 



