424 



SUBJECT INDEX 



Spleen cells, and protection against 

 runting, 291-327 

 antigens prepared from, 27 

 dose required for induction of 



tolerance, 1 50-1 51 

 injection of, causing runt disease, 

 196-200, 343, 355-360 

 effect on skin grafts, 140-141 

 inducing tolerance, 2 10-2 11 

 in prevention of runting, 293-327 

 into newborn mice, 144-149 

 irradiation producing tolerance, 



41, 42, 43 

 preimmunization with, 190 

 preparation of, 353, 379 

 transplantation of, 174-175 

 Spleen size, litter variation in, 213 

 Spleen weight, and spleen cells, 196, 

 197 

 in assay of runt disease due to 

 lymphocytes, 248-250, 257 

 Splenectomy, effect on growth of 



incompatible tumours, 225-226 

 Splenomegaly, due to graft-versus- 

 host reaction, 206-207 

 due to haemagglutinating anti- 

 bodies, 212-213 

 in runt disease, 196, 206 

 ST/A antigen, response to in factor of 



immunization, 190-194 

 Stem cell hypothesis, 207 

 Strain differences, in Factor of Im- 

 munization, 194-196 

 Strain-specificity, loss of, in tumour 



transplantation, 175-178 

 Structure, and antigenic activity, 



45-46 

 Sugars, in antigens, 11, 61, 62 

 Synergism, between sessile and 

 humoral antibodies, no, 217-218, 

 227-228, 231-232 

 Synergistic effect, 42 



Terminology, 2, 4 



Thymectomy, and adoptive im- 

 munity, 392 

 in leukaemia, 3 84, 402 

 effect of age on results, 398 

 effect on allogeneic skin grafts, 



389-391 

 effect on antibody production, 384 

 effect on immune response, 294, 395 

 effect on lymphocytes, 394, 399 

 effect on lymphoid tissue, 388-389 

 effect on white cell counts, 388 

 technique of, 385 



tumour development following, 

 402-403 

 Thymus, antibody formation in, 403 

 barrier against entry of cells, 393, 



400 

 in runt disease, 327, 401 

 irradiation of, 401-402 

 non-cellular factor from, 395-396, 



397 

 origin of immunologically com- 

 petent cells, 292 

 relation with spleen, 395 

 repopulation by cells, 397, 398, 401 

 role in immunological response, 



J93,40i 

 role in lymphocyte migration, 399 

 role in transplantation tolerance and 



immunity, 384-403 

 structure of, 400 

 Thymus grafting, 385, 392 

 Thymus transfer, 398, 400 

 Thyroid grafts, 105 

 Thyroid homografts, residence in 



eye, 5 

 Tolerance, 408-411 

 abohtion of, 382 



acquired, and factor of immuniza- 

 tion, 205-206 



enhancement and, 323-324 

 adaptive period, 318 

 and cellular changeover, 155, 156 

 and enhancement, 407 



