65. TEMPERATURE AND pH VS SERUM pK': MAN, DOG 



This nomogram allows for calculation of serum pK' for carbonic acid in man and dog when pH and temperature are 

 known. Mean pK' at 37.50C and pH 7.40 = 6.090. 



Temp 

 °C 



45 — 



pK' 



pH 



40- 



35 — 



30- 



•b.OO 



-6.02 



.8.0 



6.04 



.b-Ofc 



.i.a 



6.08 



6.10 



6.12 



6.11 



.l.b 



.T.* 



25 



20_ 



15 — 



10 — 



• b.lfe 



6.18 



.1.2 



.1.0 



6.28 

 6.30 



J. Appl. Physiol. 9:197, 1956. 



Contributor : Severinghaus, J. W. 



Reference : Severinghaus, J. W., Stupfel, M.. and Bradley, A. F. 



66. H2CO3 DISSOCIATION CONSTANTS: MAN, DOG, OX 

 The first apparent dissociation constants of H2CO3 are the same for man, dog, and ox. Methods used were gasoraet- 

 ric or glass electrode. Values in parentheses are ranges, estimate "c" of the 95% range (cf I ntroduction). 



HI Range varies with pH (7.6-7.1). /2/ Variation with pH; pK' = 7.27 5-0. 1 8 pH. / 3/ Variation with pH; 



pK' = 7.120-0.18 pH. 



Contributors : Bartels, H., and Opitz, E. 



References : [ I] Wiesinger, K., Rossier, P. H., Saboz, E.. and Sampholo, G., Helvet. physiol. pharra. acta 



7:(suppl.C) 28, 1949. [2] Cullen, G. E., Keeler, H. R., and Robinson, H. W., J. Biol. Chem. 66:301, 1925. 



[3] Dill, D. B., Daly, C, and Forbes, W. H.. ibid IT?: 569, 1937. [4] Hastings, A. B., Sendroy, J.. Jr., and 



Van Slyke, D. D.. ibid 79:183, 1928. 



63 



