59. ARTERIO- VENOUS LACTATE AND PYRUVATE DIFFERENCES IN VARIOUS STRUCTURES: MAN 

 Methods: C = colorimetric, highly specific, greatly delayed collection technique [ 1 ]; D = distillation, relatively 

 high (non-specific), delayed collection technique [2,3]; E = colorimetric, extremely rapid collection [ 1,4]; F = 

 colorimetric, fairly rapid collection [ 1,5); M = colorimetric, not arterio-venous but arm vein minus hepatic vein, 

 directional value only [ 1,6] ; R = fairly specific, extremely rapid collection; S = specific, moderately rapid collec- 

 tion [ 5,6] ; U = unknown collection technique, analysis completely specific (chromatographic); Y = very specific, 

 extremely rapid collection [4]. All values taken in state of complete rest. Values in parentheses are ranges, 

 estimate "b" of the 95% range (cf Introduction). 



Concentrations 



III Venous concentration algebraically subtracted from arterial concentration, i.e., negative values indicate output 



by the various structures. 



Contributor; Huckabee, W. E. 



Reference s: [ l] Barker, S. B., and Summerson, W. H., J. Biol. Chera. JJ8:535, 1941. [2] Edwards, H. T., ibid 



IZb^.bll. 1938. [3] Friedemann. T. E., Cotonio, M., and Shaffer, P. A., ibid 73:335, 1927. [4] Huckabee, W. E., 



J. Appl. Physiol. 2:163, 1956. [5] Friedemann, T E., and Haugen, G. E., J. Biol. Chem. 1_44:67, 1942. 



16] Friedemann, T. E., and Haugen, G. E., ibid M7:415, 1943. [7] Gibbs. E. L., Lennox, W. G., Nirams. L. F., 



and Gibbs, F. A., ibid M4:325, 1942. [8] Bay, E., Barron, E. S., Adams, W., Case, T., Halstead, W. C, 



Ricketts, H. T., Committee on Medical Research, Office of Scientific Research and Development, Rept. No. 344, 



1944. [9] Decker. D. G., and Rosenbaum, J. D., Am. J. Physiol. \1&:1 . 1942. [10] Huckabee, W. E., J. CUn. 



Invest. 21:255, 1958. [ll] Himwich, W. A., and Himwich, H. E., J. Neurophysiol. 9:1 33. 1946. [12] Bock, A. V., 



Dill, D. B., and Edwards, H. T., J. Clin. Invest. 12:775, 1932. [13] Weiss, S., and Ellis, L. B., Arch. Int. M. 



55:665, 1935. [14] Hallock, P., J. Clin. Invest. 1J:385, 1939. [15] Friedemann, T. E., Haugen, G. E., and 



Kmieciak, T. C, J. Biol. Chera. J_57:673, 1945. [16] Bueding, E., and Goldfarb, W. J., ibid 141^:539, 1940. 



[17] Seligson, D., McCormick, G. J., and Sborov, V., J. Clin. Invest. 31^:661 , 1952. [18] Andres, R., Cader, G., 



and Zierler, K. L., ibid 35:671, 1956. [19] Huckabee, W. E., unpublished. [20] Goodale, W. T., Olson. R. E., 



and Hackel, D. B., Fed. Proc. 9:49. 1950. [21] Mendeloff. A. I., J. Clin. Invest. 33:1298, 1954. 



60. ARTERIO-VENOUS POSTABSORPTIVE GLUCOSE DIFFERENCES: MAN 

 Values are rag/100 ml. Those in parentheses are ranges, estimate "c" of the 95% range (cf Introduction). 



/I/ Copper iodoraetric analysis on zinc sulfate-barium hydroxide filtrate; anticoagulant = potassium oxalate- 



sodium fluoride; accuracy = 1 mg/100 ml. /2/ Finger-tip blood, demonstrated to be arterial in character. 



/3/ Analytical method and accuracy not stated. /4/ Radial artery. /5/ Analytical method of Folin and Wu (1920). 



Contributor : Hegnauer, A. H. 



References : ( l] Soraogyi, M., J. Biol. Chem. 174:189, 



1927. [3] Foster, G. L., J. Biol. Chera. 55:291, 1923. 



1948. [2] Rabinowitch, I. M., Brit. J. Exp. Path. 8:76. 



59 



