58. ARTERIO-VENOUS O2 AND CO2 DIFFERENCES; MAN. DOG, MONKEY 



Single observation on each subject, unless otherwise specified. All blood gases measured by raanometric method 

 of Van Slyke and Niell [ l], with the exception of Line 6, Column D (measured by method of Roughton and 

 Scholander [ 2]). Values in parentheses are ranges, estimate "c" of the 95% range, unless otherwise specified (cf 

 Introduction). 



Animal 



Subjects 



Physiologic State 



A-V I V-A I Metabolic Blood 

 O2 CO2 I Rate Flow Reference 

 vol % I vol % I ml 02/min I ml/ 100 g/min 



(A) 



(B) 



(C) 



(D) 



(E) 



(F) 



(G) 



(H) 



Systemic' 



/I/ Venous samples: Lines 1 and 2, right auricle or ventricle via catheter; Lines 3-7, pulmonary artery via 

 catheter. Arterial samples: all from brachial or femoral artery. /2/ Thirteen normal males and 1 1 male patients 

 with normal cardiovascular function. /3/ Female patients with normal cardiovascular function. 1 41 Intensity of 

 exercise indicated by corresponding metabolic rates. /5/ Represents only 10 observations. /6/ Venous samples: 

 Lines 8 and 9, jugular bulb via needle puncture; Line 10, cannulation of both internal jugulars; Line 11, sagittal 

 sinus via cannula. /7/ Thirty-four observations. /8/ Measured by method of Kety and Schmidt [ 11]. /9/ Venous 

 samples: Lines 12 and 13, catheterization of coronary sinus. /lO/ Measured by an adaptation of the nitrous oxide 

 method of Kety and Schmidt [11]. 



Contributor : Hegnauer, A. H. 



References: [ l] Van Slyke, D. D., and Niell, J. M., J. Biol. Chem. 6|:523, 1924. [2] Roughton, F. J., and 

 Scholander. P. F., ibid 218:541, 1943. [3] Cournand, A., Riley, R. L., Breed, E. S., Baldwin, E. de F., and 

 Richards, D. W., Jr., J. Clin. Invest. 24:106, 1945. [4] Riley, R. L., Himmelstein, A., Motley, H. L., Weiner, 

 H. M., and Cournand, A., Am. J. Physiol. 1^:372, 1948. [5] Goodale, W. T., Lubin, M., Eckenhoff, J. E., 

 Hafkenschiel, J. H. , and Banfield, W. G., Jr., ibid 152:340, 1948. [6] Eckenhoff, J. E., Hafkenschiel, J. H., 

 Foltz, E. L., and Driver, R. L., ibid 1^2:545, 1948~T''] Kety, S. S. , and Schmidt, C. F., J. Clin. Invest. 27:476, 

 1948. [8] Kety. S. S., Woodford, R. B., Harmel, M. H., Freyhan, F. A., Appel, K. E., and Schmidt, C. F., Am. 

 J. Psychiat. 1M:765, 1947-48. [9] Schmidt, C. F., Kety, S. S., and Pennes, H. H., Am. J. Physiol. 143:33. 1945. 

 I 10] Lougheed, W. M., and Kahn. D. S., J. Neurosurg. _11;22<>. 1955. [U] Kety, S. S., and Schmidt, C. F.. Am. 

 J. Physiol. 143:53, 1945. 



SB 



