135. ANTAGONISTS AND POTENTIATORS OF DRUGS ACTING ON THE BRONCHI (Continued) 



Part I: PARASYMPATHOLYTICS AND LOCAL ANESTHETICS (Continued) 

 C = constricts, D = dilates, A = antagonizes active drug effect, I = inactive (i.e., without influence on effect of 

 active drug. Parentheses in Columns F and H Indicate action is slight, irregular, or doubtful, and the original 

 literature should be consulted. 



Antagonist 

 (Synonym) 



Active Drug 



Compound 



Effect 



Species 



Antagonist Effect 



Local 



(ig/ml [Action 



Systemic 



mg/kg I Action 



Reference 



(A) 



(B) 



(C) 



(D) 



(E) 



(F) 



(G) 



(H) 



<I) 



86 

 87 

 88 

 89 

 90 

 91 



92 

 93 

 94 

 95 



96 

 97 



98 



99 



Atropine (Tropine 



tropate)(c oncluded) 

 Bellafolinel 



d-Tubocurarine 



Dog 



0.2 



Xysmalobinum 



Cat 



Histamine 



Man 



0.01 



Methacholine 



Man 



0.01 



46 



86 



42 



42 



bis-[ 1 - ( Carbo- p-diethyl- 

 aminoethoxy) - 1 - phenyl- 

 cyclopentane] - ethane di- 

 sulphonate(SKF 769 Jz) 



Dibucaine (Nupercaine) 



Furmethide 



Guinea pig 



50 



Histamine 



Guinea pig 



75 



Histamine 



Guinea pig 



Dibutoline (Dimethyl- 

 ethyl- p-hydroxyethyl- 

 ammonium sulphate 

 di-n-butyl carba mate) 



2, 2-Diphenyl-4- 

 diisopropylamino- 

 butyramide methyl- 

 iodide (R 79) 



Histamine 



Guinea pig 



100 



Methacholine 



Guinea pig 



0.6 



Pilocarpine 



Guinea pig 



Acetylcholine 



Guinea pig 



5- Hydroxytryptamine 



Guinea pig 



87 



(A) 



87 



54 



50,88 



50 



88 



57 



57 



Homatropine sulphuric 

 ester 



Pilocarpine 



Ox 



400 



d-Hyoscine^ (Scopine 



Muscarine 



tropate) 



100 I d-Hyoscyamine^ 



(Tropine tropate) 



101 jl-Hyoscyamine^ 



102 I 



Pig 



Muscarine 



Pig 



Muscarine 



Cat 



103 [Xidocaine (Lignocaine; 

 Xylocaine) 



Pig 



89 



69 



69 



64 



69 



5 - Hydroxytryptamine 



Cat 



104 Methantheline (Banthine; 



p- Diethylaminoethyl 



105 I xanthene-9-carboxylate 



106 methobromide 



Acetylcholine 



Guinea pig 



0. Os- 

 lo. 



Histamine 



Guinea pig 



10 



(A) 



107 Novatropine 



Methacholine 



Guinea pig 



0.5-3 



51,91 



51,91.92 



51,92 



Acetylcholine 



Guinea pig 



0.05- 

 0.1 



108 

 109 

 110 

 111 

 112 



113 

 114 

 115 



116 

 117 

 118 

 119 

 120 

 121 

 122 

 123 

 124 

 125 

 126 

 127 

 128 

 129 

 130 

 131 



Frog 



0.3 



(A) 



Histamine 



Guinea pig 



10 



2-3 



12 



99 



12,93 



Procaine (Novocaine; 

 P.A.D.; p-Amino- 

 benzoyl-diethylamino- 

 ethanol) 



Acetylcholine 



Man 



50 



Guinea pig 



Diisop ropylfluoro- 

 phosphate 



Dog 



20-40 



Histamine 



Man 



Hydroxyphenyl- benzyl 

 trimethylammonium 

 dimethylcarbamate 



Guinea pig 



(A) 



Dog 



100 



5 - Hydroxytryptamine 



Physostigmine 

 Pilocarpine 



Propantheline 

 (Pro- Banthine) 



Acetylcholine 



Histamine 



5 -Hydroxytryptamine 



Methacholine 



M eth yl- furmethide 



Nicotine 



Cat 



.P<?g^ 



100-200 



Guinea pig 



Guinea pig 



0.2-10.0 



Guinea pig 



0.2-10.0 



Guinea pig 

 Guinea pig 



I.O-IO.O 



0.1-10.0 



Guinea pi g 



0.2-2.0 



Guinea pig 



1.0-10.0 



94 



95 



96 



(A) 



4.52,54,94 



95 



95 



94 



16 



16 



16 



16 



16 



16 



Scopolamine (l^Hyoscine; 

 Scopine tropate) 



Acetylcholine 



Dog 



O.l-lO 



Arecoline 



Dog 



0.1-10 



11 



n 



Histamine 



Man 



0.005-0.01 



(A) 



42 



Methacholine 



Man 



0.005-0.01 



42 



Muscarine 



Cat 



64 



Pig 



69 



Physostigmine 



Dog 



0.1-10 



11 



/I / Belladonna alkaloids, IZl Dextro isomer of scopolamine. /3/ Dextro isomer of atropine. /4/ Levo isomer of 

 atropine. 



228 



