749 



distribution 



of indicator concentration as a func- 

 tion of time, 609 



of input and output of indicator 

 \'ersus time, 603 

 experimental transit time and indicator 



transit time, 591 

 factors aflTecting, 435 

 femoral arteriovenous fistula and, 431 

 frequency histogram of times, 590 

 from perfusion of heart and lungs, 575 

 graphic representation of mean transit 



time, 593 

 localization of tricuspid regm-gitation, 



437 



recirculating system, indicator con- 

 centration versus time, 598 



schema 



of "closed"' flow system, 588 



of intercommunicating flow system, 



595 

 shunts, quantitation and localization 



of, 43 '-434. 436 

 valvular incompetence and, 436 

 valvular regurgitation and, 432, 435, 



648 

 venous 



definition, 429 



normal, 433 

 Indicator-dilution methods 



blood volume not constant and, 595 

 collecting catheter and, 604 

 constant injection, 587 

 curves, continuous recording, 429 

 distribution function, formal expression, 



604-606 

 empirical expressions, 605 

 equations for sudden- and constant- 

 injection, 592 

 for blood flow and volume, 583, 587, 



588 

 for heart models, 613 

 formal expressions for the distribution 



function, 604 

 in heterogeneous fluids, 596 

 injection rate and, 602-604 

 laminar flow through straight tubes, 



606 

 noninstantaneous sudden injection, 602 

 nonstationary system, 595 

 probability functions and, 609 

 recirculation and, 397-602 

 relation of the model to real vascular 



systems, 394 

 sudden injection, 387 

 theoretical approaches, 606-611 

 unclosed system, 394 

 washout from mixing chamber, 6 1 1 -6 1 3 

 Indicators 



definition, 385 



exchange rates and blood flow rates, 



618 



mathematics of blood flow with, 623- 



640 

 mixing and distribution, 619-620 

 tracer concept, 620-623 

 Indocyanine green 



indicator-dilution curves and, 433 

 Inspiration 



effect on heart, 705 

 left heart murmurs and, 724 

 right heart murmurs and, 724 

 vascular \olume of lung and, 703 

 InsiJin 



cardiac glycogen and, 209 

 V wave and, 383 

 Intradex: see Dextran 

 Inulin 



measurement of cardiac extracellular 

 space, 1 58 

 Iodine 



distribution in body, 620 

 isotopic, diagnosis of congenital cardiac 

 defects and, 428 

 Ionic equilibrium potential 



Nernst equation and, 242 

 Ionic exchange 



equation for, 257 

 Ionic theory 



cardiac action potential and, 262 

 Ions 



concentration 



bioelectric potentials and, 159 

 in homeometric autoregulation of 

 \entricle, 499 

 mo\'ement 



through membranes, 240 

 veratrum alkaloids and, 181 

 Iron 



isotopic, red cell labeling and, 41 

 Isotopes: see names of individual isotopes; 

 Tracer studies ; Tracers 



Jugular \enous pulse 

 carotid pulse and, 703 

 phonocardiography and, 691, 703 



K-strophanthoside: see Cardiac glycosides; 



Digitalis bodies 

 Kidney 



blood flow 



in congestive heart failure, 672 

 in mitral stenosis, 672 

 function 



in mitral stenosis, 673 

 plasma expanders and, 75 

 hematocrit from, 33 

 Krypton-85 



blood flow and, 380 

 diagnosis of congenital cardiac defects 

 and, 428 



Lactic acid 



pulmonary oxidations and, 370 



Lactic acid dehydrogenase 



in heart muscle, 207, 228 



in skeletal muscle, 228 

 Laminar flow 



definition, 138 

 Lawson, H. C. 



Volume of blood — a critical examina- 

 tion of methods for its measurement, 



^3-49 

 Lead field 



definition, 332 

 Leake, C. D. 



Historical development of cardio- 

 vascular physiology, 11-22 

 Left ventricle: see Ventricle, left 

 Leonard, E. 



Action of electrolytes and drugs on the 

 contractile mechanism of the cardiac 

 muscle cell, 131-197 

 Levan 



antigenic properties, 70 



as plasma expander, 64 



metabolism of, 68 

 Lewis, D. H. 



Phonocardiography, 695-734 

 Lipids 



of heart muscle, 204 

 Lithium 



cardiac contractility and, 163-164 



physiological effects of, 163 



sodium, potassium flux and, 164 



transport of, 1 64 

 Li\er 



blood flow, tracers and, 641 



function, plasma expanders and, 75 

 Lungs 



blood flow at rest and exercise, 573 



congestion, heart lesions and, 668 



fluid, CO-2 combination with, 571 



hematocrit, 33 



vascular volume 



expiration and, 707 

 inspiration and, 705 

 Lutembacher syndrome 



definition, 420, 473 

 LVED (left ventricular end diastolic) 

 pressure 



aortic and mitral regurgitation and, 661 



diastolic length of ventricular myo- 

 cardium and, 495 



left atrial pressure and, 313 



norepinephrine and, 492, 301 

 resistance to ventricular ejection and, 



494 

 stroke work, and myocardial segment 



length, 491-492 

 ventricular stroke work and, 509 

 Lymph 



dye remosal in, 38 



flow, pulmonary congestion and, 672 



Macrose: see Polyvinylpyrrolidone 



