Age Changes in Red Blood Cells 205 



has been observed. The eventual association of the difference 

 in red cell electrolytes with a difference in haemoglobins and 

 with a difference in cell size is discussed. 



In vitro studies of foetal erythrocytes and, particularly, 

 their interpretation, are handicapped by a fast rate of spon- 

 taneous haemolysis in foetal blood. In man this may be 

 retarded by exposing the blood to nitrogen and/or by admin- 

 istering ascorbic acid to the mother before delivery, but even 

 so the rate of spontaneous haemolysis remains far above that 

 observed in adult blood. 



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