148 



Nathan B. Talbot and Robert Richie 



the 12-hour and especially those on the six-hour regimens 

 used almost fully their normal adult ranges of renal excretory 

 adjustment in the course of each 24-hour period. When the 

 homeostatic adjustments in water and electrolyte excretion 

 exhibited by these adult subjects are viewed with relation to 

 the infant ranges of homeostatic adjustment indicated by the 

 shaded zones of the left-hand sections of Fig. 5, it can be seen 



% INCREASE 



IN 

 BODY CONTENT 



10- 



5- 



Fig. 7. Percentage increases in body water, sodium and potassium content 

 (a) which actually occurred (black sections) during the 6-hour infusion period 

 in the 6-hour regimen subjects of Figs. 5 and 6; (b) which would have occurred 

 in these adults (adult potential levels), and (c) which would have occurred in 

 a small infant (5-week infant potential), had no homeostatic increase in output 

 rates above basal levels occurred. 



that they are considerably greater than those of which such 

 young individuals are capable. 



Fig. 7 depicts the percentage increases in body water, 

 sodium and potassium content which would occur during the 

 course of the infusion period if a day's total maintenance 

 allotment of 1,500 ml. per m.^ per 24 hours * were adminis- 

 tered in six hours to a patient who was unable to increase 

 rates of urinary output above the physiologically low levels 

 characteristic of fasting and thirsting, a situation which one 



* This is an ordinary allotment for infants and children on our Service. 



