174 



Ji^f Krecek, et al. 



This is even more evident in the case of cortexone. This 

 was administered by the same route as the former substance 



23 days 



33 days 



Renal 

 water 

 loss 



Renal 



sodiiira 



loss 



Renal 



potassium 



loss 





^q/100 g 

 -450 



300 

 150 







dZI 



controls 



cortexone o.l 



cortexone 1.0 



Fig. 4. The effect of different doses of cortexone, administered for six days, 

 on renal loss of water, sodium and potassium during the first three hours after 

 administration of a water load (4-5 ml./lOO g. body wt.) to young rats aged 



23 and 33 days. 



but in doses of • 1 and 1 mg./lOO g. body weight. Results are 

 shown in Fig. 4. Lower doses of cortexone had an effect 

 similar to cortisone, quantitatively different in younger and 



