282 



Z. Fejfar 



It 



differs from that 

 an increase in CO and by vaso- 



muscular effort in healthy subjects. 



found in heart failure by 



dilatation in the skin due to increased temperature. 



Haemodynamic changes in heart failure therefore do not 

 represent a new and special adaptation of the organism to the 



Fig. 5. Changes in cardiac output (CO), peripheral 

 vascular resistance (TPR), blood pressure (P), right 

 auricular pressure (RAP) and renal plasma flow 

 (PAH) after Dibenamine in a subject with heart 

 failure. See text for details. (Fejfar, Z. (1957). 

 Acta cardiol. (Brux.), 12, 13.) 



diminishing performance of the heart. They are a typical 

 reaction which appears in every situation in which CO is 

 inadequate for oxygen requirement in the tissues. This 

 reaction becomes a chronic feature during the development of 

 congestive failure and leads to retention of water and sodium. 



i 



