References 189 



non-electrolytes (Fig. 9.8) as a function of salivary flow rate and 

 found that the results could best be interpreted on the assumption 

 of two routes of transfer, one, a fixed permeability through which 

 movement of the substance depended mainly on its lipoid solu- 

 bility, and a second whose permeability increased with flow rate 

 and through which the movement of molecules depended mainly 

 on their radius. Subsequent analysis by Burgen and Seeman (1958) 

 suggests that this second path is in the duct system. There are in 

 the literature numerous reports of the presence in saliva of anti- 

 biotics, vitamins, and miscellaneous organic molecules but few of 

 these have been studied in any detail (for a comprehensive biblio- 

 graphy see Pigman and Reid, 1952). The concentrations of most 

 of these substances in the saliva can be predicted from the rules 

 given above. 



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