METABOLISM OF THE CENTRAL NERVOUS SYSTEM IN VIVO 



l86l 



of the symptoms associated with various neurotic 

 and psychotic disturbances. The classical psycho- 

 somimetic drug, lysergic acid diethylamide (LSD-25), 

 has been found to be without effect on the cerebral 

 oxygen and glucose metabolism in both normal man 

 and schizophrenic patients, even when administered 

 in doses sufficient to produce its characteristic psycho- 

 logical effects ( 1 78). Chlorpromazine, one of the more 

 commonly employed tranquilizing drugs, has also 

 been found to be without effect on the human 

 cerebral oxygen consumption (35, 130). It does, 

 however, cause an elevation of the ATP level, prob- 

 ably by reduced utilization, in various parts of the rat 

 brain, chiefly in the midbrain but also to a lessei 

 extent in the cerebellum, cerebral cortex and medulla, 

 in that order (68). The paucity of alterations in 



cerebral metabolism found in states of altered psycho- 

 logical functions, such as exist in schizophrenia or are 

 produced by agents such as the psychosomimetic and 

 tranquilizing drugs, suggests that these functions 

 involve processes too subtle to be detected by our 

 present technique, or metabolic systems not yet 

 subjected to our investigations. Psychological func- 

 tions appear to be a product not only of the metabolic 

 processes within the cells but probably to a far greater 

 extent of the interaction of the neurons of the central 

 nervous system. They represent the ultimate de- 

 velopment of the main function of the nervous 

 system, which is communication, and their under- 

 standing awaits the unraveling of the physicochemical 

 mechanisms underlying the processes of communi- 

 cation among the cellular elements of that system. 



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