392 



URIST, MACDONALD, MOSS, AND SKOOG 

 CASE Bl. S. 



PHOSPHORUS BALANCE 



PROLINE 



OXYTETRACYCLINE i 



CASE Bl. S. 



OXYTETRACYCLINE | 



GM 

 12 

 10 

 8 

 6 



4 

 2 

 



n^-^ 



NITROGEN BALANCE 



URINARY EXCRETION 



' '-' ""T-i ^j « ^ vj 



J 



FECAL EXCRETION 



iii[im | ii]][iill | iiiniiii | iiiniiii|iiii | i i ]i 

 I '2 3 '4 '5 6*7 ' 8 9 10 



FIVE-DAY PERIODS 



GM 



1.6 H 



1.4 



1.2 



1.0- 

 08- 

 0.6- 

 0.4- 

 02 

 00 



MG% 



5 

 -4 

 ■3 



URINARY EXCRETION 



iiiiiiiiiiiiiirn 



FECAL EXCRETION 



GM 



08 

 06 

 04 

 02 

 00 



CALCIUM BALANCE 



URINARY EXCRETION 



FECAL EXCRETION 



234'56'7'8'9'I0 

 FIVE-DAY PERIODS 



MG% 



12 



II 

 10 



Fig. 3. Metabolic balance studies for nitrogen, calcium, and phosphorus in 

 Case No. 7, showing loss of nitrogen, phosphorus, and calcium in the pretreat- 

 ment period, restoration of equilibrium during oral administration of proline, 

 and return to negative calcium balance during treatment with intramuscular 

 injections of proline. 



detected by means of whole body counting in Case No. 7. The close 

 correspondence between the results of excretion as determined bv 

 retention in the skeleton and assay of absolute amounts of Sx^'' in 

 the urine and feces demonstrated that the use of a whole body 

 counting facility can eliminate the costly and more time-consuming 

 balance studies for calcium in the future. The osteogram and Bauer- 



